Efficient Inhibition of Avian and Seasonal Influenza A Viruses by a Virus-Specific Dicer-Substrate Small Interfering RNA Swarm in Human Monocyte-Derived Macrophages and Dendritic Cells
Identifieur interne : 000093 ( Main/Exploration ); précédent : 000092; suivant : 000094Efficient Inhibition of Avian and Seasonal Influenza A Viruses by a Virus-Specific Dicer-Substrate Small Interfering RNA Swarm in Human Monocyte-Derived Macrophages and Dendritic Cells
Auteurs : Miao Jiang [Finlande] ; Pamela Österlund [Finlande] ; Veera Westenius [Finlande] ; Deyin Guo [République populaire de Chine] ; Minna M. Poranen [Finlande] ; Dennis H. Bamford [Finlande] ; Ilkka Julkunen [Finlande]Source :
- Journal of Virology [ 0022-538X ] ; 2019.
Abstract
In spite of the enormous amount of research, influenza virus is still one of the major challenges for medical virology due to its capacity to generate new variants, which potentially lead to severe epidemics and pandemics. We demonstrated here that a swarm of small interfering RNA (siRNA) molecules, including more than 100 different antiviral RNA molecules targeting the most conserved regions of the influenza A virus genome, could efficiently inhibit the replication of all tested avian and seasonal influenza A variants in human primary monocyte-derived macrophages and dendritic cells. The wide antiviral spectrum makes the virus-specific siRNA swarm a potentially efficient treatment modality against both avian and seasonal influenza viruses.
Url:
DOI: 10.1128/JVI.01916-18
PubMed: 30463970
PubMed Central: 6364019
Affiliations:
- Finlande, République populaire de Chine
- Finlande occidentale, Guangdong, Uusimaa
- Helsinki, Jiangmen, Turku
- Université d'Helsinki
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Le document en format XML
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Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Expert Microbiology Unit, Department of Health Security, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Osterlund, Pamela" sort="Osterlund, Pamela" uniqKey="Osterlund P" first="Pamela" last="Österlund">Pamela Österlund</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Expert Microbiology Unit, Department of Health Security, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Expert Microbiology Unit, Department of Health Security, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Westenius, Veera" sort="Westenius, Veera" uniqKey="Westenius V" first="Veera" last="Westenius">Veera Westenius</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Expert Microbiology Unit, Department of Health Security, National Institute for Health and Welfare, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Expert Microbiology Unit, Department of Health Security, National Institute for Health and Welfare, Helsinki</wicri:regionArea><wicri:noRegion>Helsinki</wicri:noRegion></affiliation></author><author><name sortKey="Guo, Deyin" sort="Guo, Deyin" uniqKey="Guo D" first="Deyin" last="Guo">Deyin Guo</name><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>School of Medicine, Sun Yat-sen University, Guangzhou, People’s Republic of China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Medicine, Sun Yat-sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Poranen, Minna M" sort="Poranen, Minna M" uniqKey="Poranen M" first="Minna M." last="Poranen">Minna M. Poranen</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Bamford, Dennis H" sort="Bamford, Dennis H" uniqKey="Bamford D" first="Dennis H." last="Bamford">Dennis H. Bamford</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki</wicri:regionArea><orgName type="university">Université d'Helsinki</orgName><placeName><settlement type="city">Helsinki</settlement><region type="région" nuts="2">Uusimaa</region></placeName></affiliation></author><author><name sortKey="Julkunen, Ilkka" sort="Julkunen, Ilkka" uniqKey="Julkunen I" first="Ilkka" last="Julkunen">Ilkka Julkunen</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Institute of Biomedicine, University of Turku and Turku University Hospital, Turku, Finland</addr-line></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea>Institute of Biomedicine, University of Turku and Turku University Hospital, Turku</wicri:regionArea><placeName><settlement type="city">Turku</settlement><region type="région" nuts="2">Finlande occidentale</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Virology</title><idno type="ISSN">0022-538X</idno><idno type="eISSN">1098-5514</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In spite of the enormous amount of research, influenza virus is still one of the major challenges for medical virology due to its capacity to generate new variants, which potentially lead to severe epidemics and pandemics. We demonstrated here that a swarm of small interfering RNA (siRNA) molecules, including more than 100 different antiviral RNA molecules targeting the most conserved regions of the influenza A virus genome, could efficiently inhibit the replication of all tested avian and seasonal influenza A variants in human primary monocyte-derived macrophages and dendritic cells. The wide antiviral spectrum makes the virus-specific siRNA swarm a potentially efficient treatment modality against both avian and seasonal influenza viruses.</p></div></front></TEI><affiliations><list><country><li>Finlande</li><li>République populaire de Chine</li></country><region><li>Finlande occidentale</li><li>Guangdong</li><li>Uusimaa</li></region><settlement><li>Helsinki</li><li>Jiangmen</li><li>Turku</li></settlement><orgName><li>Université d'Helsinki</li></orgName></list><tree><country name="Finlande"><noRegion><name sortKey="Jiang, Miao" sort="Jiang, Miao" uniqKey="Jiang M" first="Miao" last="Jiang">Miao Jiang</name></noRegion><name sortKey="Bamford, Dennis H" sort="Bamford, Dennis H" uniqKey="Bamford D" first="Dennis H." last="Bamford">Dennis H. Bamford</name><name sortKey="Jiang, Miao" sort="Jiang, Miao" uniqKey="Jiang M" first="Miao" last="Jiang">Miao Jiang</name><name sortKey="Julkunen, Ilkka" sort="Julkunen, Ilkka" uniqKey="Julkunen I" first="Ilkka" last="Julkunen">Ilkka Julkunen</name><name sortKey="Osterlund, Pamela" sort="Osterlund, Pamela" uniqKey="Osterlund P" first="Pamela" last="Österlund">Pamela Österlund</name><name sortKey="Poranen, Minna M" sort="Poranen, Minna M" uniqKey="Poranen M" first="Minna M." last="Poranen">Minna M. Poranen</name><name sortKey="Westenius, Veera" sort="Westenius, Veera" uniqKey="Westenius V" first="Veera" last="Westenius">Veera Westenius</name></country><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Guo, Deyin" sort="Guo, Deyin" uniqKey="Guo D" first="Deyin" last="Guo">Deyin Guo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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